If I only print 2" x 4" on photo paper and not the full 4" x 6" paper, can I rewind/reuse the cartridge?

The used ribbon cannot be reused. If you are using your printer to print more 2 x 4" scale photos, we recommend that you stitch the 3 images together before printing, then print out the photos with a Liene 4 x 6" photo printer, then crop them to fit your stitching for a 2 x 4" photo.